Originally Posted by DiP

I don't think you can do that in KR, yet. Not anything to do with castspell macro (just putting the spell in a hot bar, or in a macro should be fine) but having it target your rune (automatically) may be a problem.

Unless there's something I missed.

Edit: Tabbitha posted a FAQ on some of this I think, but I think it targeted a runebook, so maybe it could work the same with a rune.